Entries by Amar Safdar

Non-myeloablative allogeneic transplantation (‘microallograft’) for refractory myeloma after two preceding autografts: feasibility and efficacy in a patient with active aspergillosis.

Singhal S, Safdar A, Chiang KY, Godder K, van Rhee F, Garner F, Foster B, Dubovsky D, Henslee-Downey PJ, Mehta J. Bone Marrow Transplant. 2000 Dec;26(11):1231-3. Abstract A 59-year-old man with a 4-year history of light chain myeloma relapsing after two preceding autografts and salvage therapy with thalidomide underwent a peripheral blood stem cell (PBSC) […]

Infections in 100 cord blood transplantations: spectrum of early and late posttransplant infections in adult and pediatric patients 1996-2005.

Safdar A, Rodriguez GH, De Lima MJ, Petropoulos D, Chemaly RF, Worth LL, Shpall EJ, Rolston KV, Raad II, Chan KW, Champlin RE. Medicine (Baltimore). 2007 Nov;86(6):324-33. Abstract Cord blood-derived stem cells are successfully used in the treatment of cancer and congenital disorders in children. This alternative source of stem cells is also explored for […]

Difficulties with fungal infections in acute myelogenous leukemia patients: immune enhancement strategies.

Safdar A. Oncologist. 2007;12 Suppl 2:2-6. Abstract Invasive fungal infection in severely immunosuppressed patients with acute myelogenous leukemia (AML) remains a serious challenge because (a) of the higher rates of non-drug susceptible fungal sinopulmonary disease; (b) despite advances in diagnostic fungal assays, the correct identification of causative organism(s) is difficult, and antifungal drug susceptibility data […]

Human herpesvirus-6 DNAemia in immunosuppressed adult patients with leukemia at risk for mold infection.

Chemaly RF, Torres HA, Hachem R, Kontoyiannis DP, Safdar A, Raad II. Haematologica. 2008 Jan;93(1):157-8. Abstract Little is known about human herpesvirus-6 (HHV-6) in leukemia patients. We prospectively followed 37 leukemia patients at risk for mold infection. HHV-6 DNA was detected from whole blood specimens in 11 patients (30%). History of granulocyte transfusions (p=0.05) and […]

Fungal endophthalmitis in a tertiary care cancer center: a review of 23 cases.

Lamaris GA, Esmaeli B, Chamilos G, Desai A, Chemaly RF, Raad II, Safdar A, Lewis RE, Kontoyiannis DP. Eur J Clin Microbiol Infect Dis. 2008 May;27(5):343-7. Abstract Few data exist on the etiology, presentation, prognosis, and management of fungal endophthalmitis (FE) in cancer patients. FE cases were identified by reviewing the ophthalmology reports and microbiology […]

Stenotrophomonas maltophilia: changing spectrum of a serious bacterial pathogen in patients with cancer.

Safdar A, Rolston KV. Clin Infect Dis. 2007 Dec 15;45(12):1602-9. Abstract Stenotrophomonas maltophilia colonization/infection in patients with cancer has significantly increased over the past 2 decades. Patients with prolonged neutropenia, exposure to broad-spectrum antibiotics, and those requiring mechanical ventilation have higher risk of infection. These micro-organisms are intrinsically resistant to carbapenems, and exposure to these […]