Entries by Amar Safdar

Fungal osteoarticular infections in patients treated at a comprehensive cancer centre: a 10-year retrospective review.

Kumashi PR, Safdar A, Chamilos G, Chemaly RF, Raad II, Kontoyiannis DP. Clin Microbiol Infect. 2006 Jul;12(7):621-6. Abstract This study reviewed retrospectively the clinical characteristics of 28 cancer patients with fungal osteoarticular infections (FOAIs) between 1995 and 2005. Most patients (26; 93%) had haematological malignancies (19 had leukaemia); half (14) were allogeneic stem-cell transplant recipients. Twelve […]

Influence of type of cancer and hematopoietic stem cell transplantation on clinical presentation of Pneumocystis jiroveci pneumonia in cancer patients.

Torres HA, Chemaly RF, Storey R, Aguilera EA, Nogueras GM, Safdar A, Rolston KV, Raad II, Kontoyiannis DP. Eur J Clin Microbiol Infect Dis. 2006 Jun;25(6):382-8. Abstract Pneumocystis jiroveci pneumonia is a common infection in patients with AIDS but an infrequent cause of pneumonia in cancer patients. Little is known about the impact of cancer type […]

Invasive fungal infections in patients with hematologic malignancies in a tertiary care cancer center: an autopsy study over a 15-year period (1989-2003).

Chamilos G, Luna M, Lewis RE, Bodey GP, Chemaly R, Tarrand JJ, Safdar A, Raad II, Kontoyiannis DP. Haematologica. 2006 Jul;91(7):986-9. Epub 2006 Jun 1. Abstract We evaluated autopsy-proven invasive fungal infections (IFI) in patients with hematologic malignancies over three periods (1989-1993, 1994-1998, and 1999-2003). The autopsy rate declined significantly (67%-34%-26%, respectively p<0.0001). IFI were identified […]

Recombinant interferon gamma1b immune enhancement in 20 patients with hematologic malignancies and systemic opportunistic infections treated with donor granulocyte transfusions.

Safdar A, Rodriguez GH, Lichtiger B, Dickey BF, Kontoyiannis DP, Freireich EJ, Shpall EJ, Raad II, Kantarjian HM, Champlin RE. Cancer. 2006 Jun 15;106(12):2664-71. Abstract BACKGROUND: The response to antifungal therapy alone often is suboptimal in patients with cancer who have therapy-refractory neutropenia, and even donor-derived granulocyte transfusions (GTX) are not always successful. The authors […]

Culture-positive and culture-negative endocarditis in patients with cancer: a retrospective observational study, 1994-2004.

Yusuf SW, Ali SS, Swafford J, Durand JB, Bodey GP, Chemaly RF, Kontoyiannis DP, Tarrand J, Rolston KV, Yeh E, Raad II, Safdar A. Medicine (Baltimore). 2006 Mar;85(2):86-94. Abstract Endocarditis is uncommon in patients with cancer. The characteristics of culture-positive (CPE) and culture-negative endocarditis (CNE) in high-risk cancer patients are not known; therefore we sought to […]

Aerosolized ribavirin-induced reversible hepatotoxicity in a hematopoietic stem cell transplant recipient with Hodgkin lymphoma.

Chaves J, Huen A, Bueso-Ramos C, Safdar A, Vadhan-Raj S. Clin Infect Dis. 2006 Apr 15;42(8):e72-5. Epub 2006 Mar 13. Erratum in: Clin Infect Dis. 2006 May 15;42(10):1512.  Abstract We describe a case of acute hepatic toxicity associated with aerosolized ribavirin in a bone marrow transplant recipient with documented respiratory syncytial virus infection. The temporal relationship […]

Central venous catheter and Stenotrophomonas maltophilia bacteremia in cancer patients.

Boktour M, Hanna H, Ansari S, Bahna B, Hachem R, Tarrand J, Rolston K, Safdar A, Raad I. Cancer. 2006 May 1;106(9):1967-73. Abstract BACKGROUND: Stenotrophomonas maltophilia bacteremia is frequently found in cancer patients. This study attempted to determine how often the catheters were the source of this infection and the risk factors associated with catheter-related bacteremias. […]

Vancomycin tolerance, a potential mechanism for refractory gram-positive bacteremia observational study in patients with cancer.

Safdar A, Rolston KV. Cancer. 2006 Apr 15;106(8):1815-20. Abstract BACKGROUND: The clinical significance of infections caused by vancomycin-tolerant (Vt) gram-positive organisms in patients with cancer remains unclear. METHODS: Twenty-five patients with nonenterococcal gram-positive bloodstream infection, which was refractory to vancomycin therapy, were identified by reviewing the Infectious Diseases consultation database at the tertiary care cancer […]