Entries by Amar Safdar

Neuraminidase inhibitors improve outcome of patients with leukemia and influenza: an observational study.

Chemaly RF, Torres HA, Aguilera EA, Mattiuzzi G, Cabanillas M, Kantarjian H, Gonzalez V, Safdar A, Raad II. Clin Infect Dis. 2007 Apr 1;44(7):964-7. Epub 2007 Feb 14. Abstract We reviewed the records of 33 patients with leukemia who experienced influenza during the period from October 2000 to March 2004. Three (38%) of the 8 patients […]

Scedosporium infection in a tertiary care cancer center: a review of 25 cases from 1989-2006.

Lamaris GA, Chamilos G, Lewis RE, Safdar A, Raad II, Kontoyiannis DP. Clin Infect Dis. 2006 Dec 15;43(12):1580-4. Epub 2006 Nov 9. Abstract We reviewed the records of patients with cancer who had Scedosporium infection (due to Scedosporium apiospermum and Scedosporium prolificans in 21 and 4 patients, respectively). The incidence of Scedosporium infection increased from 0.82 […]

Oral topical cidofovir: novel route of drug delivery in a severely immunosuppressed patient with refractory multidrug-resistant herpes simplex virus infection.

Sims CR, Thompson K, Chemaly RF, Shpall EJ, Champlin RE, Safdar A. Transpl Infect Dis. 2007 Sep;9(3):256-9. Epub 2007 Jul 1. Abstract We present a case of serious treatment-refractory acyclovir- and foscarnet-resistant herpes simplex virus (HSV) type-1 orolingual infection that responded to oral cidofovir rinses after failure of acyclovir and foscarnet therapy. The use of 3% […]

Characteristics and outcome of respiratory syncytial virus infection in patients with leukemia.

Torres HA, Aguilera EA, Mattiuzzi GN, Cabanillas ME, Rohatgi N, Sepulveda CA, Kantarjian HM, Jiang Y, Safdar A, Raad II, Chemaly RF. Haematologica. 2007 Sep;92(9):1216-23. Epub 2007 Aug 1. Abstract BACKGROUND AND OBJECTIVES: Little is known about respiratory syncytial virus (RSV) infection in patients with leukemia. The aim of this study was to determine the characteristics, […]

Inhaled corticosteroids stabilize constrictive bronchiolitis after hematopoietic stem cell transplantation.

Bashoura L, Gupta S, Jain A, Couriel DR, Komanduri KV, Eapen GA, Safdar A, Broglio KR, Adachi R, Dickey BF. Bone Marrow Transplant. 2008 Jan;41(1):63-7. Epub 2007 Oct 15. Abstract Post transplantation constrictive bronchiolitis (PTCB) is the most common pulmonary complication among long-term survivors of allogeneic hematopoietic stem cell transplantation (HSCT). It is a late manifestation […]

Dose-related safety and immunogenicity of baculovirus-expressed trivalent influenza vaccine: a double-blind, controlled trial in adult patients with non-Hodgkin B cell lymphoma.

Safdar A, Rodriguez MA, Fayad LE, Rodriguez GH, Pro B, Wang M, Romaguera JE, Goy AH, Hagemeister FB, McLaughlin P, Bodey GP, Kwak LW, Raad II, Couch RB. J Infect Dis. 2006 Nov 15;194(10):1394-7. Epub 2006 Oct 6. Abstract In 27 patients randomized to receive commercial trivalent influenza vaccine (TIV) containing 15 microg of the […]

Respiratory viral infections in adults with hematologic malignancies and human stem cell transplantation recipients: a retrospective study at a major cancer center.

Chemaly RF, Ghosh S, Bodey GP, Rohatgi N, Safdar A, Keating MJ, Champlin RE, Aguilera EA, Tarrand JJ, Raad II. Medicine (Baltimore). 2006 Sep;85(5):278-87. Abstract Community respiratory viruses (CRVs) have been recognized as a potential cause of pneumonia and death among hematopoietic stem cell transplantation (HSCT) recipients and patients with hematologic malignancies. We reviewed the Microbiology […]

Strategies to enhance immune function in hematopoietic transplantation recipients who have fungal infections.

Safdar A. Bone Marrow Transplant. 2006 Sep;38(5):327-37. Review. Abstract The challenges in the treatment of systemic fungal infections after HSCT include: (1) changing epidemiology as less drug-susceptible saprophytic fungi are increasingly associated with human disease; (2) the difficulty of early and correct diagnosis, even with the new generation of enzymatic immunoassays; (3) the inability to […]

Changing trends in etiology of bacteremia in patients with cancer.

Safdar A, Rodriguez GH, Balakrishnan M, Tarrand JJ, Rolston KV. Eur J Clin Microbiol Infect Dis. 2006 Aug;25(8):522-6. Abstract The present study was conducted to determine trends in the quantitative bacterial load patterns of bacterial bloodstream infections (BSI) caused by various bacteria in patients receiving care at a comprehensive cancer center. Bacterial loads of all […]